Line-ups: Napoli v Red Star Belgrade
Napoli rely on Lorenzo Insigne and Dries Mertens against revitalised Red Star Belgrade, as a win here and PSG failing to beat Liverpool would secure qualification.
It kicks off at the Stadio San Paolo at 20.00 GMT.
The Partenopei are currently leading the ‘Group of Death’ on six points, level with Liverpool, followed by Paris Saint-Germain on five and Crvena Zvezda on four.
That means a victory this evening and PSG failing to beat Liverpool would book their spot in the Champions League Round of 16.
As they drew 0-0 in Belgrade, and Liverpool lost there 2-0 earlier this month, it’s not a result to be taken for granted.
Lorenzo Insigne has scored in each of his last three Champions League appearances and a fourth would put him in the same pantheon as Alessandro Del Piero for Juventus in 1997-98.
The only Italians to have done better in this tournament are Del Piero in 1995-96 with five games and Milan’s Pippo Inzaghi on six in 2002-03.
Mertens gets the nod ahead of Arkadiusz Milik to partner Insigne, with Jose Callejon and Fabian Ruiz out wide.
Once again in the Champions League, Ancelotti has opted for Nikola Maksimovic at right-back, effectively making Napoli use a three-man defence when going forward and pulling Mario Rui back for 4-4-2 in defence.
Red Star Belgrade were expected to be the minnows of the group, but they have four points and are still in the running.
Their away form has been costly, losing 6-1 at Paris Saint-Germain and 4-0 in Liverpool.
There are some injury problems, as Richmond Boakye (formerly of Juventus, Genoa and Atalanta), Vujadin Savic, Filip Stojkovic and Goran Causic are out of action.
Milan Pavkov, who scored a brace against Liverpool, and Dusan Jovancic also went in carrying knocks, so are only on the bench.
The last time Napoli fired blanks at the San Paolo in all competition was 0-0 with Fiorentina on December 10, 2017. That was followed by 46 goals in 23 official matches.
Napoli last failed to score in a home Champions League match in the 0-0 with Dinamo Kiev on November 23, 2016. They have scored 11 in the next six European fixtures.
Napoli: Ospina; Maksimovic, Albiol, Koulibaly, Mario Rui; Callejon, Allan, Hamsik, Fabian; Insigne, Mertens
Napoli bench: Karnezis, Hysaj, Malcuit, Diawara, Rog, Zielinski, Milik
Red Star Belgrade: Borjan; Gobelijic, Degenek, Babic, Rodic; S Srnic, Krsticic, Simic, Marin; Ben Nabouhane; Stoiljkovic
Red Star bench: Popovic, Pavkov, Ebecilio, Jonathan Cafu, Joveljic, Jovancic, Sumalia
Ref: Manzano (ESP)
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