Line-ups: Atalanta v Napoli
Napoli once again rely on Lorenzo Insigne and Dries Mertens in a very tricky trip to Atalanta, who start Duvan Zapata and Emiliano Rigoni.
It kicks off at the Stadio Azzurri d’Italia in Bergamo at 19.30 GMT.
The Partenopei need a victory to stop Juventus running away 11 points clear at the top, while it is also an opportunity to break further away from Inter, Milan and Lazio.
Raul Albiol is carrying a knock after the Champions League win over Red Star Belgrade, but is in the starting XI anyway, as is Mario Rui.
Adam Ounas joins Simone Verdi and Vlad Chiriches on the treatment table.
Once again, Mertens and Insigne form the front two, with Arkadiusz Milik on the bench, as Carlo Ancelotti sticks with the exact same XI that beat Red Star 3-1 midweek.
That is largely because Nikola Maksimovic’s presence allows Napoli to play with three at the back when attacking, moving to four in defence.
Gian Piero Gasperini’s Atalanta famously play with a three-man defence and have been on sparkling form lately, winning four in a row up until the surprise 3-2 loss to Empoli.
They had been 2-0 up at the Stadio Castellani, but fumbled the lead and then fell apart after Josip Ilicic saw red for dissent.
He begins the two-match ban, so Emiliano Rigoni steps in with Papu Gomez and ex-Napoli forward Duvan Zapata for an all-South American front three.
Musa Barrow is not fully fit after laser eye surgery and Rafael Toloi has a muscular problem, so Gianluca Mancini starts in defence.
Atalanta: Berisha; Mancini, Palomino, Masiello; Hateboer, De Roon, Freuler, Gosens; Gomez, Rigoni; Duvan Zapata
Atalanta bench: Rossi, Gollini, Valzania, Reca, Bettella, Djimsiti, Tumminello, Castagne, Pessina, Ali Adnan, Pasalic, Barrow
Napoli: Ospina; Maksimovic, Albiol, Koulibaly, Mario Rui; Callejon, Allan, Hamsik, Fabian; Insigne, Mertens
Napoli bench: Karnezis, Meret, Malcuit, Luperto, Ghoulam, Hysaj, Zielinski, Younes, Diawara, Rog, Milik
See the latest Serie A predictions and betting tips with Eurotips.co.uk